Leukemia is a cancer in which the bone marrow goes into hyperdrive, overpopulating the blood with immature white blood cells.
The bone marrow transplant treatment is the first example of stem-cell-based therapy: hematopoietic (blood-forming) stem cells from a donor are used to replace a patient’s diseased marrow. At Children’s Hospital Boston, we use hematopoietic stem cell transplants to treat leukemia, in close collaboration with the Dana Farber Cancer Institute.
Scott Armstrong, MD, PhD, an affiliate member of the Stem Cell Program at Children’s, works with leukemia stem cells in order to understand what makes them different from healthy hematopoietic stem cells. READ MORE.
Leonard Zon, MD, discovered a new use for the drug PGE2, which may boost production of blood stem cells in patients undergoing treatment for leukemia or lymphoma. This new use of PGE2 started Phase I clinical trials in May 2009.